Bruker software suite (Data Analysis, BioPharma Compass)
Alexander Stolz
Mass Spectrometry Expert
Summary
Experienced scientist with a strong background in mass spectrometry with a special focus on (intact) protein analysis. Completed a PhD focused on the development of multidimensional capillary electrophoresis (CE) and LC-MS methods for protein characterization. Proven expertise in the industry with extensive experience in intact protein analysis and peptide mapping. Adept at driving innovative research projects and enhancing analytical capabilities to support scientific and industrial objectives.
Overview
7
7
years of professional experience
Work History
Team Leader Mass Spectrometry
Proteros Biostructures GmbH
04.2024 - Current
- Responsibility for the constant operation of the MS facility; Method and data management of all mass spectrometry data
- Evaluation and implementation of new technologies and instruments (including purchase of mass spectrometer and equipment to expand capacities)
- Implementation of a new MS-based technique (affinity selection-mass spectrometry)
- Supervised and mentored a research associate, and leading the recruitment and interviewing process for new scientists to expand the MS team
Protein Scientists Mass Spectrometry
Proteros Biostructures GmbH
02.2023 - 03.2024
- In-depth characterisation of in house produced proteins of different classes (e.g. kinases, membrane proteins, multi-protein complexes, and mAbs) by intact protein MS and peptide mapping
- Reporting and communication of results to colleagues and customers
- Troubleshooting and maintenance of analytical devices
- Evaluation of new workflows, methods, technologies and instruments
Postdoctoral Researcher
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
4 2022 - 01.2023
- Support in the setup of new laboratories in Munich and Penzberg
- Selection, planning, and purchasing of scientific instruments including: Nextgeneration sequencing (NGS), q/ddPCR, FACS, microscopy, HPLC and microfluidic fabrication (PDMS)
- Support with LC-MS research projects with the Fraunhofer ITMP cooperation partner LMU clinic Munich.
PhD Student
Aalen University
04.2018 - 03.2022
- Development and technical realisation of a nanoLC-CE-MS platform and its application to the separation of proteins from complex biological samples
- Technical design, construction, and characterisation of a novel nanoflow sheath liquid interface for CE-MS based on 3D-printed parts
- Development of top-down CE-MS methods for the in-depth characterisation of glycated and carbamylated haemoglobin from clinical and veterinary samples
- Supervision of bachelor/ master thesis, organisation of lab courses.
Master Thesis
Aston University
08.2017 - 02.2018
- Extraction of proteins from the sarcoplasmic reticulum of mice muscle tissue
- Analysis and quantification of oxidative modifications by Western blotting and nanoLC-MS/MS.
Education
Ph.D. - Chemistry/Pharmacy
Aalen University / University of Jena
Aalen, Germany 04.2001 -
Bachelor of Science - Chemistry
Aalen University
Aalen, Germany 04.2001 -
Master of Science - Analytical And Bioanalytical Chemistry
Aalen University
Aalen, Germany 04.2001 -
Skills
MS-based Protein Analysis
Mass Spectrometry (technical)
Proteomics
HPLC and related techniques
Software
PMI Byos
Thermo Fisher Software Suite (Freestyle, Proteome Discoverer)
Languages
German
Bilingual or Proficient (C2)
English
Bilingual or Proficient (C2)
Timeline
Team Leader Mass Spectrometry
Proteros Biostructures GmbH
04.2024 - Current
Protein Scientists Mass Spectrometry
Proteros Biostructures GmbH
02.2023 - 03.2024
PhD Student
Aalen University
04.2018 - 03.2022
Master Thesis
Aston University
08.2017 - 02.2018
Ph.D. - Chemistry/Pharmacy
Aalen University / University of Jena
04.2001 -
Bachelor of Science - Chemistry
Aalen University
04.2001 -
Master of Science - Analytical And Bioanalytical Chemistry
Aalen University
04.2001 -
Postdoctoral Researcher
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
4 2022 - 01.2023
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