Anna Rafiei Hashtchin
Berlin
Summary
A passionate researcher with almost 10 years of experience in stem cell and developmental biology, organoid science and technology, immunology, and automation. I Enjoy discussing science and learning about new research, which has helped me develop strong communication skills.
Overview
9
9
years of professional experience
12
12
years of post-secondary education
1
1
Certification
3
3
Languages
Work History
Postdoctoral Researcher
Max Delbrück Center
Berlin
09.2022 - Current
- Work on neuromuscular organoids technology; generation, analysis, high-throughput screening, and automation
- Research on development of immune cells, especifically macrophages, within neuromuscular organoids
Postdoctoral Researcher
Hannover Medical School and Novo Nordisk
06.2020 - 09.2022
- Lead scientist in a joint translational project between Hannover Medical School and Novo Nordisk
- Establishing safety assays for clinical application of iPSC-derived macrophages
- Work on continuous production of hematopoietic organoids and macrophages from human iPSCs in bioreactor platform (work is published in Nature Protocols)
PhD in Biomedicine
Hannover Medical School, Cluster of Excellence REBIRTH
Hannover
10.2016 - 06.2020
- Research on Scalable generation of iPSC-derived myeloid cells and investigating their therapeutic potential against S. aureus in pulmonary infected humanized mouse models
- Presented research findings at international conferences, department seminars, effectively communicating scientific concepts
- Author of peer-reviewed publications, and grant demonstrating strong scientific writing and data communication skills
- Reviewed and edited manuscripts, and thesis, providing constructive feedback to authors to enhance clarity and scientific
- Collaborated with interdisciplinary teams both in academic and industry, ensuring clear and effective communication of experimental findings and theoretical insights
Education
PhD - Biomedicine
Hannover Medical School
Hannover 10.2016 - 06.2025
M. Sc. - Molecular Medicine
University of Göttingen
10.2021 - 06.2025
M. Sc. - Cell and Developmental Biology
University of Guilan
01.2010 - 1 2012
B. Sc. - Biology-Animal Science
University of Guilan
01.2006 - 1 2010
Skills
- Communication
- Data Presentation
- Manuscript Edition and Revision
Grants And Publications
- Hochschulinterne Leistungsförderung (HiLF) MHH, "Antimicrobial activity of human iPSC-derived macrophages against Streptococcus pneumoniae - favoring cell-based immunotherapy for community-acquired pneumonia" to Dr. A. Rafiei Hashtchin., 02/2022, 25.000€
- Continuous human iPSC-macrophage production by suspension culture in stirred tank bioreactors, M. Ackermann
- A. Rafiei Hashtchin
- F. Manstein, M. C. Oliveira, et al., Nature Protocols, 17, 2, 513-539, 2022
- Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model, A. Rafiei Hashtchin, B. Fehlhaber, M. Hetzel, F. Manstein, et al., Blood Advances, 23, 5190-5201, 2021
- Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections, M. Ackermann, H. Kempf, M. Hetzel, C. Hesse, A. Rafiei Hashtchin, et al., Nature Communication, 9, 5088, 2018
- Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions, M. Ackermann
- F. Saleh
- S. M. Abdin
- A. Rafiei Hashtchin, et al., Stem Cell Research and Therapy, 15, 171, 2024
- Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli, M. Schinke, G. Meyer, A. Rafiei Hashtchin, Miriam Hetzel, et al., Journal of Immunology and Regenerative Medicine, 17, 100061, 2022
- Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs, S.M. Abdin, F. Mansel, A. Rafiei Hashtchin, M. Ackermann, et al., Biofabrication, 16, 3, 035017, 2024
- Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency, M. Hetzel
- T. Suzuki
- A. Rafiei Hashtchin, P. Arumugam, B. Carey, et al., Human Gene Therapy Methods, 28, 6, 318-329, 2017
Certification
Flow Jo v10 Qlucore Omics Explorer GraphPad Prism Image J/Fiji Bioinformatics data mining (Microarray, and RNAseq) Project Management in Biotech Industries (Grote-Westrick ) Good Scientific Practice and Statistics Introduction to GLP and GMP (Fraunhofer ITEM) Laboratory Animal Module (MHH)
Timeline
Postdoctoral Researcher
Max Delbrück Center
09.2022 - Current
M. Sc. - Molecular Medicine
University of Göttingen
10.2021 - 06.2025
Postdoctoral Researcher
Hannover Medical School and Novo Nordisk
06.2020 - 09.2022
PhD in Biomedicine
Hannover Medical School, Cluster of Excellence REBIRTH
10.2016 - 06.2020
PhD - Biomedicine
Hannover Medical School
10.2016 - 06.2025
M. Sc. - Cell and Developmental Biology
University of Guilan
01.2010 - 1 2012
B. Sc. - Biology-Animal Science
University of Guilan
01.2006 - 1 2010
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