Claudia Calpe-López

Research professional, adept at animal behavioral methodologies with solid background in drug addiction field, ready to contribute to innovative projects. Proven ability to support team objectives through effective research strategies and collaboration. Known for adaptability, reliability, and strong problem-solving and communication skills essential for dynamic research environments and impactful contributions.

Behavioral tests:

Cocaine, Alcohol, and Food Self-Administration, Conditioned Place Preference, 3-CRIT model of SA, Intracranial Self-Stimulation (ICSS), Elevated Plus Maze test, Light-Dark test, Novel Object Recognition test, Open Field test, Fear Conditioning test, Beetle-Mania Task, Social Interaction test, von Frey test, Cold-Hot Plate test, Tail Suspension test, Grooming test, Novelty Suppressed Feeding (NSF) test.

Biological and neurophysiological techniques:

intravenous catheter implantation (rats and mice), fiber-photometry implantation on rats, stereotactic surgery, spared nerve injury (SNI), transcardial perfusion, brains collection, intraperitoneal injection, oral injection (gavage), subcutaneous injection, cryostat, Golgi and Nissl staining.

Behavioral data collection: 

EthoVision Noldus and ANY-maze.

Statistical analysis: 

GraphPad Prism, SPSS, and Excel.

Preprint

Borruto, A. M., Kohlund, T., Renesse, M. V., Rettig, L., Leonhardt, N., Calpe-Lopez, C., ... & Wieland, S. (2024). Early-life adversity mediates a thalamo-amgydalar circuit dysfunction underlying chronic pain and anxiety. bioRxiv, 2024-12. https://doi.org/10.1101/2024.12.13.628438

Articles

Martínez-Caballero, M. Á., García-Pardo, M. P., Calpe-López, C., Arenas, M. C., Manzanedo, C., & Aguilar, M. A. (2024). Inhibition of Nitric Oxide Synthesis Prevents the Effects of Intermittent Social Defeat on Cocaine-Induced Conditioned Place Preference in Male Mice. Pharmaceuticals, 17(9), 1203. https://doi.org/10.3390/ph17091203

Borruto, A. M., Calpe-López, C., Spanagel, R., & Bernardi, R. E. (2024). Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice. Neuropharmacology, 258, 110081. https://doi.org/10.1016/j.neuropharm.2024.110081

Martínez-Caballero, M. Á., Calpe-López, C., García-Pardo, M. P., Arenas, M. C., de la Rubia Ortí, J. E., Bayona-Babiloni, R., & Aguilar, M. A. (2024). Behavioural traits related with resilience or vulnerability to the development of cocaine-induced conditioned place preference after exposure of female mice to vicarious social defeat. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 130. https://doi.org/10.1016/j.pnpbp.2023.110912

Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2023). Resilience to the short- and long-term behavioral effects of intermittent repeated social defeat in adolescent male mice. Pharmacology Biochemistry and Behavior, 227–228. https://doi.org/10.1016/j.pbb.2023.173574

Morella, I., Pohořalá, V., Calpe-López, C., Brambilla, R., Spanagel, R., & Bernardi, R. E. (2022). Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.986566

Calpe-López, C., Martínez-Caballero, M. A., García-Pardo, M. P., & Aguilar, M. A. (2022). Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice. Physiology & Behavior, 254, 113916. https://doi.org/10.1016/j.physbeh.2022.113916

Calpe-López, C., Martínez-Caballero, M. A., García-Pardo, M. P., & Aguilar, M. A. (2022). Brief maternal separation inoculates against the effects of social stress on depression-like behavior and cocaine reward in mice. Frontiers in Pharmacology, 13, 825522. https://doi.org/10.3389/fphar.2022.825522

García-Pardo, M. P., Calpe-López, C., Martínez-Caballero, M. Á., & Aguilar, M. A. (2022a). The Biology of Nitric Oxide Signaling and MDMA. In Handbook of Substance Misuse and Addictions. https://doi.org/10.1007/978-3-030-67928-6_123-1

García-Pardo, M. P., de la Rubia-Ortí J.E., Calpe-López, C., & Aguilar, M. A. (2021). Role of acute social stress in the rewarding effects of MDMA in adolescent mice. Behavioural Brain Research 410(8):113348 https://doi.org/10.1016/j.bbr.2021.113348

Calpe-López, C., Gasparyan, A., Navarrete, F., Manzanares, J., Miñarro, J., & Aguilar, M. A. (2021). Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice. Journal of Psychopharmacology, 35(7). https://doi.org/10.1177/0269881120965952

Calpe-López, C., García-Pardo, M. P., Martínez-Caballero, M. A., Santos-Ortíz, A., & Aguilar, M. A. (2020). Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice. Frontiers in Behavioral Neuroscience, 13. https://doi.org/10.3389/fnbeh.2019.00278

García-Pardo, M.P., Calpe-López, C., Miñarro, J., & Aguilar, M.A. (2019). Role of N-methyl-D-aspartate receptors in the long-term effects of repeated social defeat stress on the rewarding and psychomotor properties of cocaine in mice. Behav. Brain Res. 361, 95–103. https://doi.org/10.1016/j.bbr.2018.12.025

Literature Review

Calpe-López, C., Martínez-Caballero, M. A., García-Pardo, M. P., & Aguilar, M. A. (2022b). Resilience to the effects of social stress on vulnerability to developing drug addiction. World Journal of Psychiatry, 12(1). https://doi.org/10.5498/wjp.v12.i1.24

Book Chapter

García-Pardo, M. P., de la Rubia-Ortí, J. E., Calpe-López, C., Martínez-Caballero, M. Á., & Aguilar, M. A. (2022). Influence of Social Defeat Stress on the Rewarding Effects of Drugs of Abuse. In Neuromethods(Vol. 174). https://doi.org/10.1007/978-1-0716-1748-9_8

Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2022a). Modulation of Effects of Alcohol, Cannabinoids, and Psychostimulants by Novelty-Seeking Trait. In Neuromethods (Vol. 174). https://doi.org/10.1007/978-1-0716-1748-9_4

Calpe-López, C., Pilar García-Pardo, M., & Aguilar, M. A. (2019). Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: A review of possible mechanisms. In Molecules(Vol. 24, Issue 14). https://doi.org/10.3390/molecules24142583