Dr. Borhane Guezguez

Experienced Translational Research Scientist with a strong background in oncology, immunotherapy, and stem cell biology. Over 15 years of academic excellence and a proven track record of impactful, industry-relevant science. Skilled in leading cross-functional teams, securing competitive funding, and delivering high-impact publications that inform therapeutic strategies. Expertise lies in developing novel research methodologies, enhancing data accuracy, and building international collaborations. Committed to scientific excellence, ready to take on transformative projects in the field of life sciences and biotechnology.

Number: 25 H-index: 14 Total Number of Citations (Web of Science): 727
6 most significant publications:
1. Shah V, Giotopoulos G, Osaki H, Meyerhöfer M, Meduri E, Gallego-Crespo A, Behrendt MA, Saura-Pañella M, Tarkar
A, Schubert B, Yun H, Horton SJ, Agrawal-Singh S Dr, Hähnel PS, Basheer F, Lugo D, Eleftheriadou I, Barbash O, Dhar
A, Kühn M, Guezguez B, Gallipoli P, Yeh PS, Dawson MA, Prinjha RK, Huntly BJ, Sasca D. Acute resistance to BET
inhibitors remodels compensatory transcriptional programs via p300 coactivation. Blood. 2024. doi:
10.1182/blood.2022019306.
2. Beier AK, Ebersbach C, Siciliano T, Scholze J, Hofmann J, Hönscheid P, Baretton GB, Woods K, Guezguez B, Dubrovska
A, Markowitsch SD, Thomas C, Puhr M, Erb HHH. Targeting the glutamine metabolism to suppress cell proliferation in
mesenchymal docetaxel-resistant prostate cancer. Oncogene. 2024. doi: 10.1038/s41388-024-03059-4.
3. Sohl J, Hartmann AK, Hahlbrock J, Bartneck J, Stassen M, Klein M, Bros M, Grabbe S, Marini F, Woods K, Guezguez
B, Mack M, Schild H, Muth S, Melchior F, Probst HC, Langguth P, Radsak MP. Dithranol as novel co-adjuvant for noninvasive
dermal vaccination. NPJ Vaccines. 2022. doi: 10.1038/s41541-022-00530-9.
4. Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GQ, Galetzka D, Guezguez B, Hundemer
M, Bourdon JC, Munder M, Theobald M, Echchannaoui H. Δ133p53α enhances metabolic and cellular fitness of TCRengineered
T cells and promotes superior antitumor immunity. J Immunother Cancer. 2021 Jun;9(6):e001846.
5. Guezguez B., Almakadi M., Benoit YD., Shapovalova Z., Rahmig S., Fiebig-Comyn M., Casado FL., Tanasijevic B.,
Bresolin S., Masetti R., Doble BW., Bhatia M. GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic
State that is Predictive of Clinical Outcomes of Human Acute Leukaemia. Cancer Cell. 2016. 29(1):61-74.
6. Guezguez B., Campbell C.J.V, Boyd A.L., Karanu F., Casado F.L., Di Cresce C., Collins T.J., Shapovalova Z.,
Xenocostas A., Bhatia M. Regional Localization within the Bone Marrow Influences the Functional Capacity of Human
HSCs. Cell Stem Cell. 2013. 13(2):175-89.

• PhD. Award, 01/2005, Cancer Research France Foundation
• Graduate Scholarship, 01/2002, National Ministry of Research

American Society of Hematology (ASH)
European Hematology Association (EHA)
International Society for Hematology and Stem Cells (ISEH)
German Stem Cell Network (GSCN)
German Society for Research on Aging (DGFA)
Single Cell Omics Germany (SCOG)