Accomplished Senior Scientist from Paul Langerhans Institute Dresden, renowned for pioneering cell signaling studies in pancreatic beta cells and enhancing beta cell function research. Excelled in TIRF microscopy and high-resolution techniques, fostering international collaborations for innovation. Skilled in teaching, demonstrating ability to convey complex concepts to medical students. Expert in cell and molecular biology, showcasing a results-driven approach with a strong emphasis on collaboration and innovation.
Expertise
· Developed innovative approaches in studying cell signaling in pancreatic beta cells that allowed us to discover one of the main signaling (ICA512-STAT3/5) regulating beta cell function and regeneration.
· Acquired great expertise state of the arts technics TIRF and high resolution microscopy, CHIP etc,..
· Developed international collaboration with worldwide known laboratories to foster innovation,
· validate our key findings and solve trouble shooting with experts from various background
· Work with various animal models.
Teaching experience
· Teaching and supervision of medical student in the faculty of medicine in Dresden.
· Teaching TIRF microscopy to students of the international program at the Max Planck Institute Dresden
Cell and Molecular Biology
Various microscopy technics
Work with various animal models
High throughput screening and data mining
Patents:
- “ICA512 couples insulin secretion and gene expression in Beta-Cells ” (European Patent No. 04020912.4) [2008]
- “Pharmaceutical composition for increasing insulin secretion from pancreatic β-cells” (European Patent No. 07008880.2).
Publications last 5 years
- Müller A, Klena N, Pang S, Galicia Garcia LE, Oleksandra Topcheva O, Solange Duran A, Sulaymankhil D , Seliskar M, Mziaut H and al. Structure, interaction, and nervous connectivity of beta cell primary cilia. Nature Communication 2024
- Mziaut H, Henniger G, Ganss K, and al. MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling. Mol Metab. 2020
- Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H and al. Diabetologia, 2018.
Recent oral Presentations
- Villin-SNAP25 interaction regulates insulin secretion downstream of ICA512 signaling (EASD meeting 2022)
-miR-132 controls mouse pancreatic beta cell proliferation and survival through the Pten/Akt/Foxo3 signaling at the DDG (German Society of Diabetes, Berlin 2018)