Hristina Koceva
Jena
Summary
Strong ability to solve problems, eagerness to learn, and great speaking skills. Ready to make a great contribution to team progress and achieve successful outcomes. Looking forward to taking on new tasks and working hard to reach its own objectives.
Overview
2021
2021
years of professional experience
Work History
Biochemical Laboratory Volunteer
- Company Overview: Volunteered for a period of six months in the Biochemical Laboratory in Macedonia
- Gain basic and advanced knowledge about working in a Clinical Biochemical Laboratory
- Learn about many blood test examinations, assays of hormones/thyroid hormones/ liver enzymes/ urine examinations, and electrophoretic techniques
- Volunteered for a period of six months in the Biochemical Laboratory in Macedonia
Master Thesis Project
University Hospital Jena
10.2018 - 05.2020
- Company Overview: Member of the junior Research group “INSPIRE” in the University Hospital in Jena
- Gain basic and advanced knowledge about working with Microfluidic Biochip – Organ-on-a-chip
- Worked with different cell lines and Patient-derived human primary cells
- Gain fundamental knowledge in Immunofluorescence technique and microscopy
- Learned about how to organize and plan experiments and projects and to think scientifically
- Have the opportunity to work with the newest breakthrough in the field of genome editing—the CRISPR Cas9 system
- Member of the junior Research group “INSPIRE” at University Hospital in Jena
Biology Tutor
Delta State University
10.2013 - 01.2016
- Company Overview: Student Support Academy, Cleveland, MS (United States)
- Tutor students in the field of Biology on an individual or small-group basis
- Tutor students in specific course material and integrate study and learning strategies to promote independent learning
- Read and stay abreast of current topics in biology
- Create lesson plans and hand-outs
- Provide constructive criticism and feedback
- Student Support Academy, Cleveland, MS (United States)
Education
Doctor of Philosophy – PhD - Biochemistry II
University Hospital Jena
Jena05-2025
Master Program - Molecular Medicine
Friedrich-Schiller University
Jena, Germany05.2020
Bachelor of Science (Magna Cum Laude Diploma) - Biology, Chemistry
Delta State University
Cleveland, MS12.2016
High School Diploma - general knowledge, mathematics, natural sciences
"Dobri Daskalov" High School
Kavadarci, Macedonia06.2012
Skills
- Experimental Procedures Expertise:
- Cell culture and primary cell handling
- Cell Culture & IPSC-Derived Models:
IPSC differentiation into lung epithelial cells, endothelial cells, and monocytes
Organ-on-a-Chip technology
3D lung organoid models
- Molecular & Cellular Techniques:
CRISPR-Cas9 genome editing
Flow cytometry (CBA Assays, LegendPlex)
Immunofluorescence & Microscopy (ApoTome Imaging, ImageJ)
PCR, SDS-PAGE, Western Blot - Single-Cell & Transcriptomics Analysis:
Single-cell RNA sequencing (scRNA-seq) flow
Transcriptomic profiling of infected iPSC-derived lung models
High-throughput sequencing data interpretation - Host-Pathogen Interactions & Infections:
Viral infections (Influenza, Respiratory syncytial virus RSV)
Bacterial infections
Drug screening for infection models
Accomplishments
- Oral Presentation at EUROoCS 2021
Presented research on advanced iPSC-derived lung-on-chip models for studying host-pathogen interactions.
- Chosen Oral Presentation at WC12 in Canada
Discussed innovative approaches in organ-on-chip technology, emphasizing the 3Rs (Replacement, Reduction, and Refinement) in preclinical studies.
- Successful Mentor at Organ-on-a-Chip Workshop, MPS Nova, Lisbon, Portugal
Guided participants through hands-on sessions on microphysiological systems, focusing on iPSC-derived models and their applications in disease modeling.
- Review Article
Siwczak F, Loffet E, Kaminska M, Koceva H, Mahé M, Mosig AS. "Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction." Frontiers in Immunology, 2021.hal.science
- JoVE Paper
Koceva H, Amiratashani M, Rennert K, Mosig AS. "Immunocompetent Alveolus-on-Chip Model for Studying Alveolar Mucosal Immune Responses." Journal of Visualized Experiments (JoVE), 2024.pubmed.ncbi.nlm.nih.gov
- Book Chapter
Koceva H, et al. "Human-Induced Pluripotent Stem Cell-Based Alveolus-on-Chip Model to Study Influenza Virus A Infection." In: Influenza Virus: Methods and Protocols. Methods in Molecular Biology, vol 2553. Springer, 2023.link.springer.com
SELECTED ORAL PRESENTATIONS AND MENTORSHIP
PUBLICATIONS
Languages
English
Bilingual or Proficient (C2)
German
Intermediate (B1)
Serbian
Advanced (C1)
Timeline
Master Thesis Project
University Hospital Jena
10.2018 - 05.2020
Biology Tutor
Delta State University
10.2013 - 01.2016
Master Program - Molecular Medicine
Friedrich-Schiller University
Bachelor of Science (Magna Cum Laude Diploma) - Biology, Chemistry
Delta State University
High School Diploma - general knowledge, mathematics, natural sciences
"Dobri Daskalov" High School
Biochemical Laboratory Volunteer
Doctor of Philosophy – PhD - Biochemistry II
University Hospital Jena
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