MALARVIZHI GURUSAMY
Senior Researcher (Postdoctoral Fellow)
Münster
Summary
Postdoctoral researcher with 10+ years of experience in immunology, cardiopulmonary pharmacology, and preclinical models of inflammation and fibrosis. Proficient in developing biochemical and cell-based assays, ligand screening for orphan GPCRs, and establishing murine disease models. Skilled in molecular and cellular biology techniques with a strong track record of independent project leadership, interdisciplinary collaboration, and high-impact publications.
Overview
12
12
years of professional experience
9
9
years of post-secondary education
1
1
Certification
2
2
Languages
Work History
Postdoctoral Fellow
Max Planck Institute for Molecular Biomedicine
10.2022 - 09.2024
- Investigated endothelial S1PR1 signaling in osteoclast function and bone development.
- Studied GPCR crosstalk between endothelial and osteoclast cells (Endothelin/S1P signaling).
- Developed osteoclast differentiation assays and cytokine/ELISA assays.
- Conducted FACS sorting of endothelial cells, and performed blood cell population analysis.
- Performed confocal imaging and data analysis.
- Organized academic retreats and teaching sessions for PhD students.
- Active member of the Max Planck Postdoc Committee; involved in Science Day event planning and committee coordination.
Postdoctoral Fellow
Max Planck Institute for Heart and Lung Research
03.2018 - 09.2021
- Led project on understanding the role of orphan GPCR P2Y10 in CD4 T cells during neuroinflammation
- Independently developed T cell assays: activation, differentiation, migration, 3D chemotaxis, cytokine profiling, and FACS
- Identified autocrine/paracrine ligands (ATP, lysoPS) regulating CD4 T cell migration
- Conducted extensive ligand screening for GPCR P2Y10 using small molecule and lipid libraries via in vitro assays (TANGO, TGF shedding, calcium)
- Supervised Master’s and PhD students in experimental design and data interpretation
PhD Fellow & Researcher
Chonbuk National University
09.2012 - 12.2017
- Independently established and characterized murine models: acute/chronic asthma, sepsis, and vascular injury
- Evaluated Boehringer Ingelheim compounds in inflammation and fibrosis models
- Performed microsurgery, as well as molecular, biochemical, and immunological analyses
- Initiated interdisciplinary collaboration across research teams
- Engaged in science communication and presented research at conferences
- Taught PhD colleagues and managed laboratory equipment and supply orders
Education
Ph.D. - Biological Sciences
Chonbuk National University
South Korea 01.2012 - 01.2016
Integrated M.Sc. - Life Sciences
Bharathidasan University
01.2006 - 01.2011
Skills
Assay development & optimization (biochemical, cellular, immunological)
Ligand screening (small molecule & lipid libraries) for orphan GPCRs
FACS, 3D chemotaxis, cytokine profiling
Primary immune cell isolation & culture
Confocal & live-cell imaging
Molecular biology, siRNA assays
Preclinical murine models (inflammation, fibrosis, vascular injury)
Microsurgery, histology, and animal handling (FELASA B certified)
Project supervision, mentoring, and scientific communication
Certification
FELASA B Certificate, Animal Handling and Surgery, 01/01/18 - Present
Selected Publications
- G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration., Nat Commun., 2021
- Inhibition of mPGES-1 ameliorates acute lung injury., J Transl Med., 2021
- Kinin B1 receptor antagonist reduces airway inflammation., Pharmacol Res., 2016
- Triple-tyrosine kinase inhibition in chronic asthma models., Eur J Med Res., 2023
- Specialized post-arterial capillaries in bone remodeling., Nat Cell Biol., 2024, True
Personal Information
Nationality: Indian
Honors And Awards
- 1st Prize, CRC1366 Consortium Poster Presentation, Mannheim, 01/01/24
- 2nd Prize, 3-Minute Science Talk (Cell Signaling Technology), Germany, 01/01/21
- Travel Grant, Symposium on Airway Diseases, South Korea, 01/01/15
- Summer Research Fellowships, JNCASR, India, 01/01/10
- Best Contribution Award, OSDD Project, CSIR India, 01/01/10
Timeline
Postdoctoral Fellow
Max Planck Institute for Molecular Biomedicine
10.2022 - 09.2024
Postdoctoral Fellow
Max Planck Institute for Heart and Lung Research
03.2018 - 09.2021
PhD Fellow & Researcher
Chonbuk National University
09.2012 - 12.2017
Ph.D. - Biological Sciences
Chonbuk National University
01.2012 - 01.2016
Integrated M.Sc. - Life Sciences
Bharathidasan University
01.2006 - 01.2011
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